Специфичность
The M5/114.15.2 monoclonal antibody reacts with the mouse major histocompatibility complex class II, both I-A and I-E subregion encoded glycoproteins (I-A b , I-A d , I-A q , I-E d , I-E k , not I-A f , I-A k , or I-A s ). It detects a polymorphic determinant present on B cells, monocytes, macrophages, dendritic cells, and activated T lymphocytes from mice carrying the H-2 b , H-2 d , H-2 q , H-2 p , H-2 r and H-2 u but not from mice carrying the H-2 s or H-2 f haplotypes. The M5/114 mnonclonal antibody is reported to inhibit I-A-restricted T cell responses of the H-2 b , H-2 d , H-2 q , H-2 u but not H-2 f , H-2 k , or H-2 s haplotypes.